the 22-250 is to easy to load for... very user friendly, I use CCI Bench rest primers in everything except the 22 K-Hornet fur loads and the 375 H&H... for the fur loads I use Federal small pistol primers, 11½gr lil gun and 40gr V-Max... shoot one hole all day long...
back to the 22-250, find the bullet you want to shoot, I normally try to find something in the 45-55gr range, I was shooting a lot of the V-Max BT's... if you're shooting fur with it keep the velocity down to keep fur damage to a minimum...